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[18F]F-BODIPY-PSMA
- Development stage
- Preclinical
- Lead developer
- Saarland University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules, Peptides
- Administration
- Intravenous
01
Overview
[18F]F-BODIPY-PSMA is a bimodal (dual-imaging) radiolabeled peptidomimetic targeting the prostate-specific membrane antigen (PSMA) for the PET and fluorescence imaging of prostate cancer. It consists of a Glu-CO-Lys PSMA-binding motif conjugated via an aminohexanoic acid (Ahx) spacer to a boron-dipyrromethene (BODIPY) fluorophore. The BODIPY core is radiolabeled with fluorine-18 via Lewis-acid-catalyzed isotopic 18F/19F exchange. This dual-modality probe combines the high sensitivity and deep tissue penetration of positron emission tomography (PET) with the high spatial resolution of optical fluorescence imaging, making it a promising candidate for both non-invasive diagnostic imaging and fluorescence-guided surgery of prostate cancer.
- Other names
- [18F]F-1[18F]F-BODIPY-PSMA[18F]F-Glu-CO-Lys-Ahx-BODIPY18F-BODIPY-PSMAGlu-CO-Lys-Ahx-BODIPY 1Glu-CO-Lys-Ahx-BODIPY1Glu-CO-Lys-Ahx-BODIPY-1
02
Targets
PSMA (Prostate-specific membrane antigen)
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