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[18F]F-NYM124
- Development stage
- Unknown
- Lead developer
- Norroy Bioscience
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[18F]F-NYM124 is a next-generation radiopharmaceutical imaging agent designed for the detection of clear cell renal cell carcinoma (ccRCC). It consists of a small molecule ligand, NYM124, which specifically targets Carbonic Anhydrase IX (CAIX), a tumor-associated antigen that is highly overexpressed in ccRCC due to the von Hippel-Lindau (VHL) gene mutation. Labeled with the positron-emitting isotope fluorine-18 (18F), the tracer is used in PET/CT imaging to non-invasively identify primary and metastatic lesions with high sensitivity and specificity. Developed by Norroy Bioscience, [18F]F-NYM124 aims to address the limitations of conventional imaging and biopsy in characterizing indeterminate renal masses by providing high tumor-to-background ratios and rapid systemic clearance.
- Other names
- 18F-NYM124
02
Targets
CA9 (Carbonic anhydrase IX)
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