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[18F]F-RESCA-EPCD6
- Development stage
- Preclinical
- Lead developer
- Shanghai Jiao Tong University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[18F]F-RESCA-EPCD6 is an investigational **fluorine-18-labelled, RESCA-conjugated EPCD6 single-domain antibody fragment** developed as an EpCAM-targeted immunoPET tracer. The nanobody component selectively binds **epithelial cell adhesion molecule**, enabling PET/CT visualization of EpCAM expression in tumors. In preclinical colorectal and esophageal cancer xenograft models, the corresponding [18F]AlF-RESCA-EPCD6 construct demonstrated EpCAM-specific tumor uptake and favorable low-background pharmacokinetics. The tracer is also included in a recruiting Renji Hospital PET/CT study for diagnostic evaluation of non-small cell lung cancer and solid lung nodules.
- Other names
- [18F]AlF-RESCA-EPCD6[18F]F-EPCD6
02
Targets
EPCAM (Epithelial cell adhesion molecule)
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