[18F]F-RESCA-WWH347

[18F]F-RESCA-WWH347 is a novel radiopharmaceutical probe designed for immunoPET imaging, specifically targeting the GPA33 antigen. It utilizes the Al^18^F-RESCA (Aluminum fluoride-restrained complexing agent) method to label heat-sensitive biomolecules with fluorine-18, enabling high-specificity PET imaging of tumors expressing GPA33, such as those found in colorectal and other digestive system cancers. The RESCA chelator allows for mild and efficient radiolabeling at room temperature, preserving the integrity of sensitive proteins or antibody fragments. This probe is being investigated primarily for its ability to visualize and quantify tumor burden in patients with digestive system carcinomas using immunoPET/CT scans[1][3][9].