Drug intelligence / Profile preview

[18F]FAPI

Development stage
Preclinical
Lead developer
SOFIE
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

[18F]FAPI is a fluorine-18 labeled radiopharmaceutical developed by Oryx Isotopes for positron emission tomography (PET) imaging. It specifically targets the fibroblast activation protein (FAP), which is highly expressed in the cancer-associated fibroblasts (CAFs) of the tumor stroma across various solid tumors. By binding to FAP, the tracer allows for high-contrast imaging of the tumor microenvironment, potentially offering superior diagnostic performance compared to traditional tracers like [18F]FDG in certain cancers where glucose metabolism is low or background noise is high. It is currently in the preclinical stage of development.

Other names
Fibroblast Activation Protein Inhibitor F-18
02

Targets

FAP (Fibroblast activation protein alpha)

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