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[18F]FEPPA
- Development stage
- Phase 1
- Lead developer
- University of Toronto
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[18F]FEPPA is a radiolabeled small molecule used as a positron emission tomography (PET) imaging agent. It acts as a specific ligand for the 18 kDa translocator protein (TSPO), which is upregulated in activated microglia and macrophages during neuroinflammatory processes. As such, [18F]FEPPA serves as a biomarker for glial activation and neuroinflammation in various neurological conditions, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and long COVID. The compound is synthesized via nucleophilic substitution using a tosylated precursor and purified by HPLC to achieve high radiochemical purity suitable for injection[1][2][3][4]. Its primary use is research-based PET imaging to quantify TSPO expression in vivo.
- Other names
- [18F]FE-PBR28
02
Targets
TSPO (Translocator Protein (18 kDa))
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