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[18F]fluortriopride
- Development stage
- Phase 2
- Lead developer
- University of Pennsylvania
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]fluortriopride is a novel radiopharmaceutical used as a positron emission tomography (PET) imaging agent with high selectivity for the dopamine D3 receptor. It is designed to enable in vivo visualization and quantification of D3 receptors, which are implicated in neuropsychiatric disorders such as Parkinson's disease, dystonia, schizophrenia, and substance abuse. The compound demonstrates approximately 160-fold selectivity for the D3 receptor over the D2 receptor. Its primary use is as a research tool to study brain dopaminergic function and related pathologies using PET/CT imaging[8][1][2]. The drug was initially developed by researchers at the University of Pennsylvania.
- Other names
- N-(4-(4-(2-(2-[^18F]fluoroethoxy)phenyl)-1-piperazinyl)butyl)benzamide
02
Targets
DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)
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