[18F]NS12137

[18F]NS12137 is a radiolabeled small molecule ligand designed for positron emission tomography (PET) neuroimaging of the norepinephrine transporter (NET). It serves as a molecular probe to quantify noradrenergic innervation and signaling in the brain. By binding specifically to NET, [18F]NS12137 allows for the non-invasive assessment of noradrenergic system integrity, which is often compromised in neurodegenerative conditions such as Parkinson's disease. Research in animal models, such as the Pink1-/- rat, has demonstrated its utility in identifying reduced NET density in regions like the thalamus and prelimbic area, suggesting its potential as a biomarker for disease progression and therapeutic efficacy in disorders involving noradrenergic dysfunction. The ligand exhibits moderate test-retest reproducibility and high specificity, as evidenced by its displacement by the selective NET inhibitor nisoxetine.

Other names

6-(3-fluoropropyl)-3-(p-tolyl)-8-azabicyclo[3.2.1]oct-2-eneF-18 NS12137F18 NS12137F 18 NS12137