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[18F]PDE4B-13
- Development stage
- Preclinical
- Lead developer
- Emory University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]PDE4B-13 is a novel fluorine-18 labeled positron emission tomography (PET) tracer designed for the in vivo imaging of phosphodiesterase 4B (PDE4B) in the brain. Developed by researchers at Jinan University and Emory University, the tracer is optimized for high-affinity, specific binding to PDE4B, which is a key regulator of intracellular cAMP signaling implicated in neuroinflammation and neurodegenerative disorders such as Parkinson's disease. Preclinical evaluations in rodent and non-human primate models have demonstrated favorable brain kinetics, high brain uptake, and region-specific distribution, supporting its potential as a quantitative imaging tool for monitoring PDE4B expression and neuroinflammatory dynamics.
- Other names
- [18F]-PDE4B-13[18F]PDE4B-13 PET tracer[¹⁸F]PDE4B-13
02
Targets
PDE4B (3',5'-cyclic-AMP phosphodiesterase 4B)
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