Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
[18F]PLX5622
- Development stage
- Preclinical
- Lead developer
- University of Michigan
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]PLX5622 is a fluorine-18 labeled small molecule radiotracer developed by researchers at the University of Michigan for positron emission tomography (PET) imaging of the colony-stimulating factor 1 receptor (CSF1R). CSF1R is a tyrosine kinase receptor exclusively expressed on microglia in the brain and is robustly upregulated in neuroinflammatory conditions, such as Alzheimer's disease and related dementias. Derived from the highly selective, brain-penetrant CSF1R inhibitor PLX5622 (originally developed by Plexxikon), [18F]PLX5622 is synthesized via copper-mediated radiofluorination of a boronate precursor. It is designed to provide a next-generation PET imaging tool with high specific binding, enabling the non-invasive monitoring and quantification of microglial-specific neuroinflammation in vivo.
- Other names
- 18F-PLX-562218F-PLX5622[18F]PLX-5622
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)
Beyond the preview
Go deeper on [18F]PLX5622.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on [18F]PLX5622.