[18F]RO-948

[18F]RO-948 is a radiopharmaceutical PET imaging agent developed for the in vivo visualization and quantification of tau protein aggregates in the brain. It is a fluorine-18 labeled compound with high affinity and specificity for tau aggregates, particularly those found in Alzheimer's disease (AD), while showing minimal binding to amyloid-beta plaques or non-Alzheimer's tauopathies. The tracer enables early detection, differential diagnosis, and monitoring of neurodegenerative diseases characterized by abnormal tau accumulation, such as AD. Its improved off-target binding profile compared to earlier tracers makes it valuable for research and potential clinical use in mapping disease progression and evaluating therapeutic interventions[1][3][4][5].

Other names

18F-labelled RO 6958948[18F]6958948