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[18F]TFPFN-269-H4
- Development stage
- Preclinical
- Lead developer
- Fudan University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[18F]TFPFN-269-H4 is a mesothelin (MSLN)-targeting radiopharmaceutical developed by Fudan University for the positron emission tomography (PET) imaging of ovarian cancer. It consists of the mesothelin-specific single-domain antibody (nanobody) VHH 269-H4 labeled with the positron emitter fluorine-18 (18F) via the residualizing prosthetic agent 2,3,5,6-tetrafluorophenyl 6-[18F]fluoronicotinate ([18F]TFPFN). In preclinical studies, [18F]TFPFN-269-H4 demonstrated high specificity and affinity for mesothelin-expressing ovarian cancer cells and xenografts, showing rapid renal clearance and clear tumor visualization on microPET/CT imaging.
- Other names
- 18F-labeled VHH-269-H4[18F]TFPFN-VHH-269-H4
02
Targets
Mesothelin
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