[4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid

This compound is a synthetic small molecule belonging to the phenylpyrrole class of polycyclic aromatic compounds. It has been studied as an experimental agent and is not approved for clinical use. The primary known mechanism of action is inhibition of serine/threonine-protein kinase Sgk1 (SGK1), with reported in vitro activity (IC50 = 63 nM). There are no approved indications or ongoing clinical trials for this compound. It has also been evaluated in computational drug repositioning studies as a potential inhibitor of SARS-CoV‑2 main protease (Mpro), but there are no preclinical or clinical data supporting its use in any disease at this time[1][6].

Other names

{4-[5-(2-Naphthyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid2-(4-(5-(naphthalen-2-yl)-1H-pyrrolo[2,3-b]pyridin-3 yl)phenyl)acetic acid