Drug intelligence / Profile preview

[68Ga]AJ647

Development stage
Preclinical
Lead developer
Johns Hopkins University
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
01

Overview

[68Ga]AJ647: sourced facts only. name: "Cell uptake and competitive binding assays were conducted to test [68Ga]AJ647 specificity for nectin-4 in the presence or absence of EV." [DOI:10.1158/1538-7445.am2024-2579]; target: "Cell uptake and competitive binding assays were conducted to test [68Ga]AJ647 specificity for nectin-4 in the presence or absence of EV." [DOI:10.1158/1538-7445.am2024-2579]; developer: "1Johns Hopkins University, Baltimore, MD." [DOI:10.1158/1538-7445.am2024-2579]; modality: "we developed a nectin-4 specific peptide-based radiotracer, [68Ga]AJ647, for positron emission tomography (PET) imaging." [DOI:10.1158/1538-7445.am2024-2579]; stage: "Pharmacokinetics, biodistribution and specificity of [68Ga]AJ647 for nectin-4 expression was evaluated in six xenograft models by PET imaging and biodistribution studies." [DOI:10.1158/1538-7445.am2024-2579]

02

Targets

PVRL4 (Nectin cell adhesion molecule 4)

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