Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
[68Ga]Ga-DOTA.SA.FAPi
- Development stage
- Unknown
- Lead developer
- Heidelberg University Hospital
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[68Ga]Ga-DOTA.SA.FAPi is a next-generation radiopharmaceutical diagnostic agent designed for positron emission tomography (PET) imaging. It targets Fibroblast Activation Protein (FAP), an enzyme highly overexpressed on the surface of cancer-associated fibroblasts (CAFs) within the tumor stroma of most epithelial cancers. The molecule utilizes a squaric acid (SA) linker, which has been shown to enhance the binding affinity and pharmacokinetic profile of FAP inhibitors compared to earlier versions. By chelating the positron-emitting isotope Gallium-68 via a DOTA moiety, the tracer allows for high-contrast visualization of various malignancies, including breast and lung cancers. It is particularly noted for its low background uptake in the brain and liver, facilitating the detection of metastases in these regions where standard [18F]FDG PET/CT often has limitations.
- Other names
- 68Ga-DOTA-SA-FAPiGallium-68 DOTA-SA-FAPiGallium68 DOTA-SA-FAPiGallium 68 DOTA-SA-FAPi
02
Targets
FAP (Fibroblast activation protein alpha)
Beyond the preview
Go deeper on [68Ga]Ga-DOTA.SA.FAPi.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on [68Ga]Ga-DOTA.SA.FAPi.