[68Ga]Ga-HBED-CC-exendin-4

[68Ga]Ga-HBED-CC-exendin-4 is a radiopharmaceutical agent consisting of exendin-4, a glucagon-like peptide 1 receptor (GLP1R) agonist, conjugated to the chelator HBED-CC and labeled with the positron-emitting radioisotope gallium‑68. It is designed for use in PET imaging to target GLP1R, which is highly expressed on pancreatic β-cells and insulinomas. This agent enables sensitive and specific localization of insulinoma tumors and assessment of β-cell mass. Compared to similar agents such as [68Ga]Ga-NOTA-exendin‑4, it demonstrates comparable tumor detectability but with lower renal uptake, potentially improving detection near the kidneys. The compound shows rapid pancreatic uptake and fast renal clearance in preclinical models, supporting its utility for human imaging studies focused on diabetes or insulinoma[1][5].