Drug intelligence / Profile preview

[68Ga]Ga-NOTA-DBP1k

Development stage
Unknown
Lead developer
Southern Medical University
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
01

Overview

[68Ga]Ga-NOTA-DBP1k: sourced facts only. name: "NOTA-DBP1k showed high affinity for CD24 (KD = 10.70 ± 0.70 nM) and PD-L1 (KD = 5.40 ± 0.61 nM)." [PMID:39952064]; target: "NOTA-DBP1k showed high affinity for CD24 (KD = 10.70 ± 0.70 nM) and PD-L1 (KD = 5.40 ± 0.61 nM)." [PMID:39952064]; target: "NOTA-DBP1k showed high affinity for CD24 (KD = 10.70 ± 0.70 nM) and PD-L1 (KD = 5.40 ± 0.61 nM)." [PMID:39952064]; developer: "GDMPA Key Laboratory for Quality Control and Evaluation of Radiopharmaceuticals, Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515 Guangdong Province, China." [PMID:39952064]; modality: "In this study, by radiolabeling DBP1 peptide, we developed a novel PET modality to noninvasively evaluate CD24 and PD-L1 expressions in tumors." [PMID:39952064]; stage: "In vivo, [68Ga]Ga-NOTA-DBP1k showed high uptake in MCF-7 tumors and had favorable tumor-to-background ratios by microPET imaging." [PMID:39952064]

02

Targets

CD24 (Cluster of Differentiation 24)CD274 (Programmed cell death protein 1 ligand 1)

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