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[68Ga]Ga-NOTA-PEG2-WP8

Development stage: Unknown
Lead developer: Nanjing Medical University
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

[68Ga]Ga-NOTA-PEG2-WP8 is an investigational peptide-based radiopharmaceutical designed for noninvasive Positron Emission Tomography (PET) imaging of Trophoblast cell-surface antigen 2 (Trop2) expression. Developed by researchers at Nanjing Medical University, the tracer consists of a Trop2-targeting peptide (WP8) derived from the natural ligand midkine (MDK) via computational simulation. This peptide is conjugated to the chelator NOTA (1,4,7-triazacyclononane-triacetic acid) through a PEG2 spacer and labeled with the positron-emitting radioisotope gallium-68. Preclinical evaluations in triple-negative breast cancer (TNBC) models demonstrate that the tracer has nanomolar affinity for Trop2, favorable pharmacokinetics, and high stability, allowing for rapid and specific identification of Trop2-positive tumors. It is primarily intended as a companion diagnostic tool to monitor Trop2 expression levels and assess tumor response to Trop2-targeted antibody-drug conjugates (ADCs) such as sacituzumab govitecan and datopotamab deruxtecan.

Other names: 68Ga-labeled Trop2-targeting peptide WP8Gallium-68 NOTA-PEG2-WP8Gallium68 NOTA-PEG2-WP8Gallium 68 NOTA-PEG2-WP8

Targets

TACSTD2 (Tumor-associated calcium signal transducer 2)

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