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[68Ga]Ga-NOTA-WWH347
- Development stage
- Unknown
- Lead developer
- Renji Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[68Ga]Ga-NOTA-WWH347 is a radiolabeled nanobody-based immunoPET imaging agent designed for the non-invasive visualization of tumors expressing glycoprotein A33 (GPA33), a protein highly expressed in over 95% of human colon cancers. The agent consists of the GPA33-targeted nanobody WWH347 conjugated to the chelator NOTA and labeled with gallium-68, enabling PET/CT imaging. It has demonstrated high specificity and tumor uptake in preclinical colorectal cancer models and is being evaluated clinically for diagnostic imaging in digestive system carcinomas, particularly colorectal cancer. Its mechanism involves specific binding to GPA33 on tumor cells, allowing sensitive detection via PET/CT scans[1][2][3].
- Other names
- [68Ga]Ga-NOTA-WWH347Gallium-68 NOTA-WWH347Gallium68 NOTA-WWH347Gallium 68 NOTA-WWH347
02
Targets
GPA33 (Glycoprotein A33)
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