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[68Ga]Ga-TG3
- Development stage
- Preclinical
- Lead developer
- CHU de Bordeaux
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
[68Ga]Ga-TG3 (also referred to as [68Ga]Ga-tg3) is a radiolabeled neuropeptide-Y (NPY) analogue designed to target the neuropeptide-Y receptor type 5 (Y5R) for cancer imaging and potentially theranostic applications [1.1]. The peptide backbone, tg3 (DOTA-[cPP(1-7),NPY(19-32),Ala31,Aib32,Gln34]-hPP), is a highly selective Y5 receptor agonist [1.1]. When radiolabeled with the positron emitter gallium-68, it serves as a positron emission tomography (PET) imaging tracer [1.1]. Preclinical studies have demonstrated high affinity and selectivity for Y5R, with potential utility in imaging Y5R-overexpressing cancers such as breast and prostate cancers [1.1].
- Other names
- DOTA-[cPP(1-7),NPY(19-32),Ala31,Aib32,Gln34]-hPP[68Ga]Ga-DOTA-[cPP(1-7),NPY(19-32),Ala31,Aib32,Gln34]-hPP[68Ga]Ga-tg3
02
Targets
NPY5R (Neuropeptide Y receptor type 5)
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