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[68Ga]Ga-TTP

Development stage: Unknown
Lead developer: Peking University Cancer Hospital & Institute
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

[68Ga]Ga-TTP is a Gallium-68 labeled radiopharmaceutical developed by the Peking University Cancer Hospital & Institute. It functions as a molecular imaging probe for Positron Emission Tomography (PET) to noninvasively detect and quantify the expression of Trophoblast cell-surface antigen 2 (TROP2) in patients with breast cancer. TROP2 is a transmembrane glycoprotein frequently overexpressed in various epithelial cancers and is a key target for antibody-drug conjugates (ADCs). By visualizing TROP2 expression, [68Ga]Ga-TTP PET/CT is intended to assist in patient selection for TROP2-targeted therapies and to evaluate the efficacy of ADC treatments.

Other names: 68Ga-labeled TROP2-targeting peptide

Targets

TACSTD2 (Tumor-associated calcium signal transducer 2)

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