Drug intelligence / Profile preview

[68Ga]MLN6907

Development stage
Phase 1
Lead developer
Millennium Pharmaceuticals
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration
Intravenous
01

Overview

[68Ga]MLN6907 is a radiopharmaceutical diagnostic imaging agent developed by Millennium Pharmaceuticals (a subsidiary of Takeda). It is a Gallium-68 labeled tracer designed for Positron Emission Tomography (PET) imaging. The agent specifically targets Guanylate Cyclase 2C (GUCY2C), a transmembrane receptor protein that is normally expressed in the intestinal epithelium but is frequently overexpressed in primary and metastatic colorectal carcinoma (mCRC). By binding to GUCY2C, [68Ga]MLN6907 allows for the non-invasive detection and localization of metastatic lesions, such as liver metastases, and can be used to evaluate GUCY2C expression levels to identify patients who may benefit from GUCY2C-targeted therapeutic agents.

Other names
gallium Ga 68-labeled MLN6907[68Ga]MLN6907Gallium-68-MLN-6907Gallium68-MLN-6907Gallium 68-MLN-6907[68Ga]DOTA-MLN6907
02

Targets

GUCY2C (Guanylate cyclase C receptor)

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