[89Zr]Zr-DFO*malHSA

[89Zr]Zr-DFO*malHSA is a radiopharmaceutical imaging probe consisting of human serum albumin (HSA) site-selectively functionalized with the octadentate chelator DFO* via a maleimide linker and radiolabeled with the positron emitter zirconium-89 (89Zr). It is designed as a PET imaging agent to monitor albumin accumulation and homeostasis in malignant tissues, leveraging the enhanced permeability and retention (EPR) effect. By providing a long-lived tracer (89Zr half-life ~78.4 h) that matches the biological half-life of albumin, it serves as a companion diagnostic to stratify patients for therapies involving albumin-bound drugs or albumin-binding prodrugs.

Other names

89Zr-DFO*-malHSAzirconium-89 labeled DFO*-maleimide human serum albumin