Drug intelligence / Profile preview

[89Zr]Zr-DFO-hSR7

Development stage: Unknown
Lead developer: Union Hospital of Huazhong University of Science and Technology
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[89Zr]Zr-DFO-hSR7 is an investigational immuno-PET radiotracer designed to image Trophoblast cell-surface antigen 2 (Trop-2) expression in cancer patients. It consists of the humanized monoclonal antibody hSR7—the same antibody used in the antibody-drug conjugate sacituzumab govitecan (Trodelvy)—radiolabeled with the positron-emitting isotope Zirconium-89 (89Zr) via a deferoxamine (DFO) chelator. Administered intravenously, the tracer is used to evaluate the correlation between tracer uptake and Trop-2 expression levels, serving as a companion diagnostic to predict or monitor response to Trop-2 targeted therapies. It is currently being evaluated in exploratory clinical studies for patients with advanced triple-negative breast cancer (TNBC), pancreatic cancer, and other Trop-2 expressing malignancies.

Other names: [89Zr]Zr-DFO-hSR789Zr-DFO-sacituzumab89Zr-labeled hSR7

Targets

TACSTD2 (Tumor-associated calcium signal transducer 2)

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