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[99mTc]Tc-EDDA-HTK03180

Development stage: Preclinical
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[99mTc]Tc-EDDA-HTK03180 is an investigational **PSMA-targeted radiopharmaceutical imaging agent** for prostate cancer SPECT imaging. It is a **technetium-99m labeled small-molecule tracer** built on a lysine-ureido-α-aminoadipic acid pharmacophore and incorporates a HYNIC chelator with tranexamic acid and 9-anthrylalanine; EDDA is used as a co-ligand for technetium coordination. The tracer is designed to bind **prostate-specific membrane antigen** on prostate cancer cells and enable lesion visualization by SPECT/CT. Based on the provided preclinical literature context, it has shown tumor uptake in PSMA-expressing LNCaP xenografts with lower spleen and salivary gland uptake than comparator PSMA SPECT tracers, and it remains in **preclinical research-stage development**.

Other names: technetium Tc 99m EDDA-HTK03180

Targets

PSMA (Prostate-specific membrane antigen)

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