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[99mTc]Tc-EDDA-KL01127

Development stage: Preclinical
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

[99mTc]Tc-EDDA-KL01127 is an experimental **PSMA-targeted technetium-99m radiopharmaceutical** being developed as a **SPECT imaging tracer** for **prostate cancer**. It is a Lys-urea-Aad pharmacophore-derived small-molecule ligand labeled with technetium-99m using an EDDA-based chelation system, designed to bind **prostate-specific membrane antigen** on prostate cancer cells and enable tumor visualization after intravenous administration. In the cited preclinical study, it showed successful imaging of LNCaP xenografts, predominantly renal clearance, and lower off-target uptake in spleen and salivary glands with improved tumor-to-background contrast relative to [99mTc]Tc-EDDA/HYNIC-iPSMA, supporting potential clinical translation as a PSMA SPECT diagnostic agent.

Other names: technetium Tc 99m EDDA-KL01127

Targets

PSMA (Prostate-specific membrane antigen)

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