[Aib8]hGLP-1(7-36)NH2

[Aib8]hGLP-1(7-36)NH2 is a synthetic peptide analogue of human glucagon-like peptide-1 (GLP-1) where the native alanine at position 8 is replaced by the non-proteinogenic amino acid alpha-aminoisobutyric acid (Aib). This specific modification is designed to confer resistance against enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), which rapidly inactivates native GLP-1 by cleaving the N-terminal dipeptide. While the Aib8 substitution significantly enhances the metabolic stability and extends the plasma half-life of the peptide, it maintains high binding affinity and agonist potency for the GLP-1 receptor. This analogue served as a critical structural lead and comparison compound in the development of more advanced GLP-1 receptor agonists, such as taspoglutide (BIM-51077), which incorporates an additional Aib substitution at position 35 to further optimize its pharmaceutical profile and stability.

Other names

Aib8-GLP-1Aib-8-GLP-1Aib 8-GLP-1[Aib8]GLP-1(7-36)amideAib8-hGLP-1(7-36)NH2