[Cu2(sal-D,L-glu)2(isoquinoline)2]

[Cu2(sal-D,L-glu)2(isoquinoline)2] is a binuclear Schiff base copper(II) complex investigated for its potential as an anticancer agent. The complex consists of copper ions coordinated with N-salicylidene-D,L-glutamate and isoquinoline ligands. It functions as a proteasome inhibitor, specifically targeting the ubiquitin-proteasome pathway to induce apoptosis in tumor cells. Research has demonstrated its cytotoxic activity against various human cancer cell lines, including A549 lung carcinoma, HeLa cervix carcinoma, and U-118MG glioblastoma cells. By inhibiting proteasome activity, the complex leads to the accumulation of ubiquitinated proteins, triggering programmed cell death.

Other names

[Cu2(sal-D,L-glu)2(isoquinoline)2] . 2C2H5OHbis(isoquinoline)bis(N-salicylidene-D,L-glutamato)dicopper(II)