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[F-18]RGD-K5
- Development stage
- Unknown
- Lead developer
- Cleveland Clinic
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
[F-18]RGD-K5 is an investigational radiopharmaceutical developed by The Cleveland Clinic for the detection of unstable atherosclerotic plaques using positron emission tomography (PET) imaging. The tracer consists of a cyclic peptide containing the arginine-glycine-aspartic acid (RGD) motif labeled with the radioisotope fluorine-18. It specifically targets the alpha-v beta-3 (αvβ3) integrin, a cell surface receptor that is significantly upregulated on neovascular endothelial cells and activated macrophages within inflamed, vulnerable plaques. By localizing to these areas of high inflammation and angiogenesis, [F-18]RGD-K5 allows for the non-invasive identification of carotid artery lesions at high risk of rupture, potentially assisting in the selection of patients for carotid endarterectomy.
- Other names
- F-18 RGD-K5F18 RGD-K5F 18 RGD-K518F-RGD-K5
02
Targets
αVβ3 (Integrin αVβ3)
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