[phenylalaninyl-prolinyl]-[2-(pyridin-4-ylamino)-ethyl]-amine

[phenylalaninyl-prolinyl]-[2-(pyridin-4-ylamino)-ethyl]-amine is a synthetic small molecule dipeptide derivative. It has been studied in the context of thrombin inhibition, where it acts as a peptide mimetic with an aminopyridine group substituting for guanidine in classical thrombin inhibitors. The compound occupies the active site of thrombin, projecting its aminopyridine and central hydrophobic groups into key subsites (S1, S3), and forms close contacts with main-chain carbonyl groups on thrombin. This suggests potential as a noncovalent inhibitor targeting the enzyme's active site[6]. There is no evidence of clinical development or approval for any indication.

Other names

(Phenylalaninyl-prolinyl)-(2-(pyridin-4-ylamino)-ethyl)-amine(2S)-1-((2R)-2-amino-3-phenylpropanoyl)-N-(2-((pyridin-4-yl)amino)ethyl)pyrrolidine-2-carboxamide(2S)-1-[(2R)-2-amino-3-phenylpropanoyl]-N-[{2-[{pyridin-4-yl}amino]ethyl}]pyrrolidine-2-carboxamidePhenylalanyl-N-[2-(4-pyridinylamino)ethyl]prolinamide[1][5][8]