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[Tc-99m]-RPI-T-087
- Development stage
- Phase 1
- Lead developer
- Reiley Pharmaceuticals
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[Tc-99m]-RPI-T-087 is a technetium-99m labeled radiopharmaceutical developed by Reiley Pharmaceuticals as a diagnostic imaging agent for osteoarthritis of the knee. It functions as a radiotracer that specifically targets cyclooxygenase-2 (COX-2), an enzyme upregulated during inflammatory processes. By binding to COX-2, the agent allows for the visualization and assessment of inflammation within the joint using SPECT/CT imaging. It is currently being evaluated in Phase 1 clinical trials to determine its safety, tolerability, and effectiveness as a biomarker for identifying inflammatory activity in patients with knee osteoarthritis compared to healthy volunteers.
- Other names
- [Tc-99m]-RPI-T-087 Injection
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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