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(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide is an experimental small molecule inhibitor of dihydroorotate dehydrogenase, an enzyme involved in the de novo biosynthesis of pyrimidines. It was designed as part of a structure-based drug discovery effort to develop inhibitors targeting both human and Plasmodium falciparum dihydroorotate dehydrogenases, with potential applications in immunomodulation and antimalarial therapy. The compound has demonstrated inhibitory activity against its target enzyme in biochemical assays but has not advanced to clinical development or approval[5][1][9].
- Other names
- (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamideN-[2-chloro-4-(2-methoxyphenyl)phenyl]-2-cyano-3-hydroxybut-2-enamide
02
Targets
DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)
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