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Drug intelligence / Profile preview
(R,R')-4'-methoxy-1-naphthylfenoterol
- Development stage
- Preclinical
- Lead developer
- Mitchell Woods Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral, Parenteral
01
Overview
(R,R')-4'-methoxy-1-naphthylfenoterol (MNF) is a research-stage small molecule and a bivalent analog of (R,R')-fenoterol. It acts as a highly selective β2-adrenergic receptor (β2-AR) agonist and an inhibitor of GPR55-mediated signaling. Preclinical studies have demonstrated its ability to inhibit cancer cell proliferation, motility, and invasion across various malignancies, including glioblastoma, pancreatic cancer, and hepatocarcinoma. MNF also interacts with cannabinoid receptors (CB1R), contributing to its anti-mitogenic effects. The compound was developed in part through research at the National Institute on Aging (NIA) and is associated with Mitchell Woods Pharmaceuticals.
- Other names
- (R,R')-4'-methoxy-1-naphthylfenoterol
02
Targets
GPR55 (G protein-coupled receptor 55)CNR1 (Cannabinoid receptor 1)ADRB2 (β2)
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