Drug intelligence / Profile preview

1'-acetoxychavicol acetate

Development stage
Unknown
Modality
Small Molecules
Administration
Subcutaneous, Intralesional
01

Overview

1'-Acetoxychavicol acetate is a phenol ester with a wide range of biological activities including antioxidative, anti-obesity, antibacterial, anti-parasitic, chemopreventive, and anticancer properties. It inhibits xanthine oxidase and activates TRPA1, an ion channel involved in pain signaling. It has been shown to inhibit adipogenesis, decrease visceral fat in animal models, and exhibit antitumor activities in various cancer models. Additionally, it acts as a NF-kappaB inhibitor and suppresses nitric oxide synthase production. It is naturally found in plants of the Zingiberaceae family, notably Alpinia galanga.

Other names
Galangal acetate1'-Acetoxychavicol acetateD/L-1'-Acetoxychavicol acetate(1S)-4-(acetyloxy)phenyl]prop-2-en-1-yl acetate
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)CYP1A2 (Cytochrome P450 1A2)NOS1 (nNOS)NOX4 (NADPH oxidase 4)CYP3A4 (Cytochrome P450 3A4)TRPA1 (Transient receptor potential cation channel subfamily A member 1)

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