Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
1-(1H-indazol-5-yl)-3-phenylurea
- Development stage
- Unknown
- Lead developer
- Moffitt Cancer Center
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
RKI-11 is a small molecule indazole urea-based compound that acts as a weak or inactive analogue of the Rho-associated kinase (ROCK) inhibitor RKI-18. Developed by researchers at the Moffitt Cancer Center, RKI-11 inhibits ROCK1 and ROCK2 with low potency, exhibiting IC50 values of 38 µM and 45 µM, respectively. Due to its minimal activity in suppressing the phosphorylation of the ROCK substrate myosin light chain 2 (MLC2) and its lack of effect on cancer cell migration and invasion, RKI-11 is widely utilized as a negative control or chemical probe in preclinical studies investigating the therapeutic potential of ROCK inhibition in oncology.
- Other names
- 1-(1H-indazole-5-yl)-3-phenylurea1-(1H-indazol-5-yl)-3-phenylurea3-(1H-indazol-5-yl)-1-phenylurea
02
Targets
ROCK1 (Rho-associated coiled-coil containing protein kinase 1)ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
Beyond the preview
Go deeper on 1-(1H-indazol-5-yl)-3-phenylurea.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 1-(1H-indazol-5-yl)-3-phenylurea.