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1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the class of N‑phenylureas. It features a thienopyrimidine core linked via an ethylene bridge to a thiazole ring and further substituted with a trifluoromethylphenyl urea moiety. The compound has been identified as an inhibitor of Aurora kinase A and Aurora kinase B—serine/threonine kinases involved in cell cycle regulation and mitosis. Inhibition of these kinases is being explored as an antineoplastic (anticancer/antitumor) strategy due to their role in tumor cell proliferation. The molecule is considered experimental and does not have approved therapeutic indications or known commercial developers or manufacturers at this time[1][2][5].
- Other names
- 1-(5-(2-(thieno(3,2-d)pyrimidin-4-ylamino)ethyl)-1,3-thiazol-2-yl)-3-(3-(trifluoromethyl)phenyl)urea3-{5-[2-(thieno[3,2-d]pyrimidin-4-yamino)ethyl]-1,3-thiazol-2-y}-1-[3(trifluoromethyl)phenyl]urea
02
Targets
PLK1 (Polo like kinase 1)AURKB (Aurora kinase B)AURKA (Aurora kinase A)
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