1-benzyl-3-(4-methoxyphenylamino)-4-phenylpyrrole-2,5-dione

**Description:** 1-benzyl-3-(4-methoxyphenylamino)-4-phenyll-pyrrole‑2,5‑dione is a synthetic small molecule compound with the formula C24H20N2O3 and a molecular weight of approximately 384.43 g/mol[1][5]. It is classified as an experimental drug and has not been approved for any therapeutic use in the US or other major regulatory jurisdictions[1][6]. The compound has been studied primarily as a ligand for nuclear receptors. **Mechanism of Action:** This molecule acts as an agonist at two key nuclear hormone receptors: Liver X receptor alpha (LXRα; NR1H3) and Liver X receptor beta (LXRβ; NR1H2), also known as oxysterol receptors[5]. These receptors are involved in cholesterol metabolism, lipid homeostasis, and regulation of inflammatory responses. Additionally, DrugBank lists retinoic acid receptor RXR-alpha (RXRA) as another target[1], suggesting possible activity at this heterodimerization partner. **Development Status:** There are no clinical trials or approved indications for this compound. It remains an experimental research tool used to probe LXR/RXR biology in preclinical settings[6].

Other names

1-benzyl-3-(4-methoxyphenylamino)-4-phenylpyrrole-2,5-dione1-Benzyl-3-(4-methoxyphenylamino)-4-phenyll-pyrrole-2,5-dione3-(4-methoxyphenyl)amino]-4-phenyll-(phenylmethyl)pyrrole-2,5-dioneCAS 264206–85–1