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1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
A synthetic small molecule belonging to the phenylpyrazole class. It features a pyrazolo[3,4-d]pyrimidine core substituted with a cyclobutyl group and a 3,4-dimethoxyphenyl moiety. This compound is primarily used as an experimental tool in biochemical research and has been studied for its inhibitory activity against several protein kinases. Notably, it acts as an inhibitor of tyrosine kinases such as ABL1 (Abelson murine leukemia viral oncogene homolog 1), EPHB4 (Ephrin type-B receptor 4), HCK (Hematopoietic cell kinase), mTOR (mechanistic target of rapamycin), PDGFRB (Platelet-derived growth factor receptor beta), PI3K isoforms (PIK3CA/PIK3CB/PIK3CD), PRKDC (DNA-dependent protein kinase catalytic subunit), and SRC family kinases. Its primary use is in preclinical or laboratory settings to probe kinase signaling pathways rather than clinical therapy[2][9].
- Other names
- 1-cyclobutyl-3-(3,4-dimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
02
Targets
EPHB4 (Ephrin type-B receptor 4)PDGFRB (Platelet-derived growth factor receptor beta)PIK3CA (Phosphoinositide 3-kinase alpha)ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)DNA-PK (DNA-dependent protein kinase)HCK (Haematopoietic Cell Kinase)mTOR (Mammalian target of rapamycin kinase)
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