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1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid
- Development stage
- Preclinical
- Lead developer
- Nerviano Medical Sciences
- Modality
- Small Molecules
01
Overview
A synthetic small molecule belonging to the quinazoline class of organic compounds. It is an experimental compound primarily studied as a potent inhibitor of cyclin-dependent kinase 2 (CDK2), particularly in complex with Cyclin A. The compound has demonstrated nanomolar inhibitory activity against CDK2/Cyclin A in biochemical assays and is being explored for its potential as an anti-cancer agent due to its cell cycle regulatory effects. Its development and characterization have been reported by Nerviano Medical Sciences and curated in chemical databases such as DrugBank and ChEMBL[1][3][4].
- Other names
- 8-Anilino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid1-methyl-8-(phenylamino)-1H,4H,5H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid
02
Targets
CDK2 (Cyclin-dependent kinase 2)
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