Drug intelligence / Profile preview

1-N-(4-sulfamoylphenyl-ethyl)-2,4,6-trimethylpyridinium

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
01

Overview

A synthetic small molecule belonging to the benzenesulfonamide class. It is an experimental compound that acts as a potent inhibitor of carbonic anhydrase enzymes. The compound has demonstrated high affinity for carbonic anhydrase II (Ki = 21 nM), suggesting its mechanism involves inhibition of this enzyme. Carbonic anhydrases are involved in the reversible hydration of carbon dioxide and play roles in pH regulation and fluid balance. This molecule has not been approved for clinical use and is primarily used in research settings to study enzyme inhibition[1][3][8].

Other names
2,4,6-trimethyl-1-[2-(4-sulfamoylphenyl)ethyl]pyridinium1-{2-[4-(aminosulfonyl)phenyl]ethyl}-2,4,6-trimethylpyridiniumPyridinium, 1-[2-[4-(aminosulfonyl)phenyl]ethyl]-2,4,6-trimethyl-1-N-(4-sulfamoylphenylethyl)-2,4,6-trimethylpyridinium
02

Targets

CA2 (Carbonic Anhydrase 2)

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