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111In-PSMA I&T

Development stage: Phase 2
Lead developer: Scintomics
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Small Molecules, Peptides
Administration: Intravenous

Overview

111In-PSMA I&T is an investigational radiopharmaceutical consisting of the prostate-specific membrane antigen (PSMA)-targeting peptidomimetic ligand zadavotide guraxetan (PSMA I&T) labeled with the gamma-emitting radionuclide indium-111. It is designed for single-photon emission computed tomography (SPECT/CT) imaging and radioguided surgery (RGS) in patients with prostate cancer, including newly diagnosed, recurrent, and metastatic disease. By binding specifically to PSMA overexpressed on prostate cancer cells, 111In-PSMA I&T allows for the precise intraoperative localization and resection of metastatic lymph nodes and other soft-tissue lesions using a handheld gamma probe.

Other names: [111In]PSMA-I&T111In-PSMA-I&T111In-labeled PSMA-I&T111In-zadavotide guraxetanindium (111In) zadavotide guraxetanindium In 111 zadavotide guraxetanindium-111 PSMA I&Tindium-111-PSMA-I&T

Targets

PSMA (Prostate-specific membrane antigen)

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