13-(3-trifluoromethylphenyl)parthenolide

13-(3-trifluoromethylphenyl)parthenolide is a fluorinated small molecule analog of the sesquiterpene lactone parthenolide, developed by researchers at Purdue University. It acts as an inhibitor of the NF-κB signaling pathway, specifically targeting multiple myeloma cancer stem cells (MM-CSCs) within the bone marrow microenvironment. In preclinical studies, the compound demonstrated the ability to induce apoptosis in drug-resistant MM-CSCs through the activation of caspases 8 and 3. Due to its lower cytotoxicity compared to the parent compound and the presence of fluorine atoms, it has been proposed as a potential PET imaging probe for the detection and localization of cancer stem cell niches in multiple myeloma patients.

Other names

13-(3-trifluoromethyl-phenyl)-parthenolide