14α-hydroxy-4-androstene-3,6,17-trione

14α-hydroxy-4-androstene-3,6,17-trione is a **synthetic steroidal compound** with reported **aromatase inhibitory activity**, making it potentially useful as an antitumor agent.[1] Aromatase is an enzyme responsible for converting anrogens to estrogens; inhibition of this enzyme can reduce estrogen biosynthesis, which is a target in certain hormone-dependent cancers. This compound was developed via selective oxidation of 6-β,14-α-dihydroxy-4-androstene-3,17-dione, and displays a molecular formula of C19H24O4 and a molecular weight of 316.[1][6] It is classified as a triketone and has the appearance of a white powder. The mechanism of action is analogous to that of **irreversible aromatase inhibitors**, which permanently inactivate the enzyme and thereby reduce estrogen production.[1] There is no evidence it is approved or marketed as a pharmaceutical or dietary supplement, and no information identifying any brand or code names associated with this chemical.

Other names

14-alpha-hydroxy-4-androstene-3,6,17-trione14-hydroxyandrost-4-ene-3,6,17-trione