15,16-dihydrotanshinone I

15,16-dihydrotanshinone I is a **bioactive abietane diterpenoid compound** primarily isolated from the roots of *Salvia miltiorrhiza* (Danshen)[1][2][3][4][5]. It has been employed historically in traditional Chinese medicine and is now under investigation for its pharmacological effects: - **Mechanisms of action** include anti-proliferative and anti-inflammatory activities through cell cycle arrest (G0/G1 phase), inhibition of cyclins and cyclin-dependent kinases, upregulation of p21, and modulation of key signaling pathways, notably **AMP-activated protein kinase (AMPK)** activation, and suppression of **Akt/mTOR** and **MAPK** signaling in cancer cells[3][5]. - Demonstrates **antioxidant**, **anti-inflammatory**, **antimicrobial**, and pronounced **anticancer** effects (particularly against various tumor cell lines)[1][2][3][5]. - Also studied for cardiovascular protection, neuroprotection, and skin applications[1][5]. Most data come from preclinical models; definitive human efficacy remains unproven.

Other names

dihydrotanshinone I(-)-dihydrotanshinone Idihydrotanshinone-Itanshinone I, dihydro-15,16-dihydrotanshinone-I (alternative spelling)(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione(1R)-1,6-dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dionecannabisin A standard