15-deoxy-delta-12,14-prostaglandin J2

15-deoxy-delta-12,14-prostaglandin J2 is a naturally occurring, endogenous **prostaglandin J2 derivative** of the cyclopentenone prostaglandins (J2 series) and a metabolite of prostaglandin D2. It is an **anti-inflammatory lipid mediator** and is a high-affinity endogenous ligand for the **peroxisome proliferator-activated receptor gamma (PPARγ)**. Mechanistically, it exerts its effects by: - **Activating PPARγ**, leading to inhibition of inflammatory response gene expression in a PPARγ-dependent manner, including genes such as inducible nitric oxide synthase and TNF-alpha. - **Inhibiting the NF-κB signaling pathway** at multiple steps both PPARγ-dependently and -independently, including through direct covalent modification of cysteine residues in IκB kinase and NF-κB subunits, reducing pro-inflammatory cytokines (such as IL-6, TNF-alpha, and IL-8). - Modulating AP-1 (activator protein 1) signaling and downregulating contraction- and inflammation-associated proteins. These effects contribute to a negative feedback regulation of prostaglandin biosynthesis and inflammation. 15d-PGJ2 has been investigated in preclinical models for **delaying LPS-induced preterm labor** and for its broad anti-inflammatory activities. It also acts as an electrophilic reagent and has shown anti-angiogenic and pro-apoptotic effects on endothelial cells[1][3][5][6].

Other names

15-deoxy-delta12,14-prostaglandin J215-Deoxy-PGJ215-deoxy-delta-12,14-PGJ215-Dpgj2delta12,14-PGJ2(5Z,12E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acidprosta-5,9,12,14-tetraen-1-oic acid, 11-oxo-, (5Z,12E,14E)-(Z)-7-[(1S,5E)-5-[(E)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acidCHEMBL482477CHEMBL-482477CHEMBL 482477CHEBI:3415987893-55-8J694.826JJ-694.826JJ 694.826JALI977775JALI-977775JALI 977775J