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16-[18F]fluoro-4-thiapalmitate

Development stage: Unknown
Lead developer: Indiana University School of Medicine
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

16-[18F]fluoro-4-thiapalmitate (18F-FTP) is a small-molecule positron emission tomography (PET) radiopharmaceutical developed by Indiana University. It serves as a metabolically trapped analog of palmitate, designed to assess myocardial fatty acid oxidation (FAO) rates. The tracer's mechanism involves transport into the mitochondria via carnitine palmitoyl-transferase-I (CPT-1), where it undergoes partial beta-oxidation but becomes trapped, allowing for the quantification of fatty acid metabolism. It is primarily used as a diagnostic research tool to study myocardial fuel selection in conditions such as Type 2 Diabetes (T2DM), ischemic heart disease, and nonischemic cardiac diseases.

Other names: 16-fluoro-4-thiapalmitatethiapalmitate16-18-F-fluoro-4-thiapalmitate

Targets

SLC7A1 (Cationic amino acid transporter 1)

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