2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate

**Description:** 2',3'-Dideoxy‑3'‑fluoro‑uridine‑5'‑diphosphate (FUDP) is a synthetic nucleoside diphosphate analog of uridine. It is characterized by the absence of hydroxyl groups at the 2' and 3' positions and a fluorine substitution at the 3' position on the ribose ring. This compound belongs to the class of organic pyrophosphates and nucleoside analogs[1][4]. As an experimental small molecule with no current clinical approval or known therapeutic indication[3], it is primarily used in biochemical research as a substrate or inhibitor in studies involving nucleotide metabolism and polymerase activity. Its mechanism of action likely involves interference with nucleic acid synthesis due to its structural similarity to natural uridine diphosphates.

Other names

2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate(((((2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-fluorooxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)phosphonic acid[({[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-fluorooxolan‑2‑yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid