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2',5'-Dideoxyuridine
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
01
Overview
2',5'-Dideoxyuridine is a synthetic nucleoside analog structurally related to deoxyuridine, in which both the 2' and 5' hydroxyl groups of the ribose moiety are absent. It belongs to the class of pyrimidine nucleosides. While closely related compounds such as 2'-deoxyuridine and its halogenated derivatives (e.g., idoxuridine, bromovinyldeoxyuridine) have established roles as antimetabolites or antiviral agents, there is limited information on the clinical use or pharmacological activity of specifically 2',5'-dideoxyuridine. Its mechanism of action would be expected to involve interference with DNA synthesis by incorporation into DNA in place of natural nucleosides, potentially leading to chain termination or inhibition of enzymes involved in nucleotide metabolism.
- Other names
- 2',5'-Dideoxyuridine
02
Targets
DNA polymerase family
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