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2'-3' cGAMP
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intratumoral, Intravenous, Subcutaneous
01
Overview
2'-3' cGAMP (2',3'-cyclic GMP-AMP) is an endogenous cyclic dinucleotide (CDN) produced in mammalian cells by the enzyme cyclic GMP-AMP synthase (cGAS) in response to cytosolic double-stranded DNA. It acts as a potent second messenger that binds to and activates the Stimulator of Interferon Genes (STING) receptor with high affinity. This activation triggers the TBK1/IRF3 and NF-κB signaling pathways, resulting in the induction of type I interferons (IFN-β) and various pro-inflammatory cytokines. While primarily utilized as a research reagent, 2'-3' cGAMP is being extensively studied for its potential as a vaccine adjuvant and as an immunotherapeutic agent in oncology and antiviral therapy. It is structurally distinct from the bacterial canonical 3'3'-cGAMP and is currently available from multiple chemical suppliers for laboratory use.
- Other names
- cyclic [G(2',5')pA(3',5')p]cyclic GMP-AMPcGAMP
02
Targets
STING (Stimulator of interferon genes protein)
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