2'-deoxy-2'-fluoroguanosine

2'-Deoxy-2'-fluoroguanosine is a synthetic nucleoside analog characterized by the substitution of a fluorine atom at the 2' position of the deoxyribose sugar ring of guanosine. It functions as a potent antiviral agent, demonstrating significant activity against a range of viruses, most notably influenza (A and B) and herpes simplex viruses (HSV-1 and HSV-2). The mechanism of action involves the intracellular phosphorylation of the compound to its active triphosphate form, which then competes with natural guanosine triphosphate (GTP) for incorporation into viral nucleic acids. This process leads to the inhibition of viral RNA-directed RNA polymerase (RdRp) in influenza viruses, effectively blocking viral transcription and replication. In herpesviruses, it similarly targets viral DNA polymerase. While it has been extensively studied in preclinical research for its antiviral properties, it is primarily utilized as a research tool and has not been developed into a commercial pharmaceutical product by a specific company.

Other names

2'-Fluoro-2'-deoxyguanosine2'-deoxy-2'-fluoro-D-guanosine2'-F-Guanosine2'-deoxy-2'-fluoro-guanosine